focus: Cyclin E

• Dysregulation of the cell cycle is a key mechanism for the occurence of tumors

• Cyclin E (CnE) is a key regulator of the cell cycle and when present in abnormally elevated amounts in cause cells to divide uncontrollably

• CnE is considered an 'undruggable' target as it is extremely difficult to develop small molecule inhibitors

Figure. Schematic of a bispecific antibody modified with Accum that will target HER2+ tumor cells and internalized and become trapped inside endosomes. Accum will then enable endosome escape and nuclear transport where the other binding arm will bind and inhibit CnE activity.