Our approach for drugging the undruggable
focus: Cyclin E
Dysregulation of the cell cycle is a key mechanism for the occurence of tumors
Cyclin E (CnE) is a key regulator of the cell cycle and when present in abnormally elevated amounts in cause cells to divide uncontrollably
CnE is considered an 'undruggable' target as it is extremely difficult to develop small molecule inhibitors
Figure. Schematic of a bispecific antibody modified with Accum that will target HER2+ tumor cells and internalized and become trapped inside endosomes. Accum will then enable endosome escape and nuclear transport where the other binding arm will bind and inhibit CnE activity.