Our approach for drugging the undruggable

focus: Cyclin E
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Dysregulation of the cell cycle is a key mechanism for the occurence of tumors
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Cyclin E (CnE) is a key regulator of the cell cycle and when present in abnormally elevated amounts in cause cells to divide uncontrollably
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CnE is considered an 'undruggable' target as it is extremely difficult to develop small molecule inhibitors

Figure. Schematic of a bispecific antibody modified with Accum that will target HER2+ tumor cells and internalized and become trapped inside endosomes. Accum will then enable endosome escape and nuclear transport where the other binding arm will bind and inhibit CnE activity.