The importance of studying internalization and cellular accumulation
The therapeutic effectiveness of antibody-based medicines is reliant on efficient receptor-mediated internalization and accumulation inside target diseased cells. For the past 3 decades, HER2 is the prime example of an antibody therapeutic target. However, HER2 internalization remains a mystery. Please find the article below that described and reveals the secrets behind the mystery. Moreover, you will learn how to more effectively internalize your antibodies and potentially have better therapeutic efficacy. The lessons learned are to be a template to help guide you with your own antibody-receptor systems.